6 Several of these drugs, such as Wegovy and Zepbound, were approved for use as a treatment for obesity, obstructive sleep apnea, heart attack or stroke prevention in those who have already experienced a cardiovascular event
Widespread use of these agents requires systematic perioperative strategies by anaesthetists to balance safety with therapeutic benefit
However, further research is required to ascertain the long-term outcomes of GLP-1 RAs in IBD patients, with some studies indicating potential benefits and others highlighting concerns regarding altered gut immunity
13 These findings are consistent with results from the SURPASS-1 trial, in which tirzepatide at all studied doses significantly improved HbA1c over 40 weeks without increasing hypoglycemia risk
Many researchers find that understanding the relationship between lyophilized and liquid peptide forms helps them choose the right reconstitution strategy from the start
Clinical research has evaluated doses up to 12 mg per week, depending on individual tolerance and treatment goals